To investigate the role of SLAMF7 in sepsis in vivo, we established sepsis mouse models in C57BL/6 mice by LPS injection (endotoxemia model), P. aeruginosa infection (bacterial sepsis model), or cecal ligation and puncture (CLP) (polymicrobial sepsis model) (51). Here, SLAMF7 is linked to bacterial infectious disease with sepsis.