In this study, we demonstrated that SLAMF7 was inducibly expressed on macrophages in response to TLR ligands and bacterial infection and that it interacted with SHIP1 and TRAF6 to attenuate MAPK and NF-κB signaling–mediated proinflammatory cytokine production (Supplemental Figure 14). This evidence concerns the gene NFKB1 and bacterial infectious disease.