To directly determine the role of macrophage SLAMF7 in sepsis, we generated a conditional SLAMF7fl/fl Lyz2Cre mouse by crossing mice that had loxP-flanked alleles of the SLAMF7 exon (SLAMF7fl/fl) with mice that had transgenic expression of Cre recombinase driven by the gene encoding Lyz2 (Lyz2Cre), in which SLAMF7 is specifically deleted in macrophages. The gene discussed is SLAMF7; the disease is Sepsis.