Another study suggested that the levels of Nrf2-dependent genes during diabetes, such as HO-1, NQO1, glutamate-cysteine ligase regulatory subunit (GCLM) and glutamate-cysteine ligase (GCLC), as well as the oxidative markers DHE, NT, 4-HNE, and Trx1, are restored by tubastatin A, suggesting that tubastatin A reduces oxidative stress by restoring the Nrf2-dependent pathway in the diabetic retina [20]. The gene discussed is GCLM; the disease is diabetes mellitus.