More importantly, inhibiting glucose metabolism and its associated hyperglycolysis has been reported to enhance the efficiency of hypothermia-induced neuroprotection in ischemic stroke (Han et al., 2021). In this study, PGK1 was found to critically regulate microglial cell M1 polarization and inflammation by regulating the expression of PKM2 and LDHA, which ultimately regulate glycolysis, highlighting the importance of glycolysis in microglial function. Here, PKM is linked to ischemic stroke.