BRD4 and Merkel cell skin cancer: A study demonstrated that H3K27ac is closely related to the epigenetic regulation of gene expression (Lavarone et al., 2019). Ma and Zheng demonstrated that lncRNA PAXIP1-AS1 activated by H3K27ac promotes ovarian cancer (Ma & Zheng, 2021). Disruption of BRD4 at the H3K27Ac-enriched enhancer region suppressed the expression of c-Myc in Merkel cell carcinoma (Sengupta et al., 2015). H3K27ac also contributes to inflammation and stroke.