PGK1 and neurodegenerative disease: showed that the activation of PGK1 with terazosin suppressed organ damage and increased the survival of animals with stroke (Chen et al., 2015). It has long been shown that both enhanced PGK1 activity and increased glycolysis alleviate neurodegeneration (Cai et al., 2019) and that energy deficiency may be a pathogenic factor for the pathogenesis of neurodegenerative diseases, leading to neuronal dysfunction and subsequent death (Saxena, 2012).