​There is a strong link between caspase-1-dependent pyroptosis in cardiomyocytes and the nucleotide-binding oligomerization domain-like receptor family protein 3 (NLRP3) inflammasome (Zeng et al. 2020; Miao et al. 2010).​In DCM patients, circulating levels of NLRP3 inflammasome may be associated with cardiac function and rehospitalization (Luo et al. 2013). This evidence concerns the gene CASP1 and familial dilated cardiomyopathy.