However, when comparing healthy and COPD LR-MSCs in the alveolosphere organoid model—used for assessment of regenerative capacity, the addition of COPD LR-MSCs to the human lung cell line, NCI-H441, resulted in the formation of larger organoids with lower expression levels of the type II marker, Surfactant protein C (SPC), at earlier stages. The gene discussed is SFTPC; the disease is chronic obstructive pulmonary disease.