IHC is often positive for EMA but negative for HMB-45 and Melan-A.[13] The shape of melanotic schwannoma cells is mild and arranged in a palisade shape, which can be seen in areas A and B, but negative for HMB-45 and Melan-A.[14] In addition, it needs to be distinguished from ependymoma, ganglioglioma, medulloblastoma, and other tumors, which are relatively easy to distinguish according to histological characteristics and IHC phenotype. This evidence concerns the gene MLANA and schwannoma.