NLRP3 and chronic obstructive pulmonary disease: COPD is associated with loss of GCR in senescent CD28null and NKT-like cells[65] and synthetic glucocorticoids are widely prescribed drugs for COPD.[66] A recent study demonstrated that TREM-1 aggravates the development of COPD via activating NLRP3 inflammasome-mediated pyroptosis.[67] Macrophages circulate in the blood and control innate and acquired immunity, as well as homeostasis.