TREM1 and chronic obstructive pulmonary disease: Modern pharmacological research demonstrated that AKT1 was regulated by various compounds from DHI, such as tanshinone.[63] Hydroxysafflor yellow A has been reported to alleviate increased TNF and IL6, leading to the inhibition of inflammation in patients with COPD.[64] In addition, it was observed the action of DHI against COPD was associated with the regulation of multiple pathways, such as glucocorticoid receptor signaling, TREM1 signaling, and production in macrophages.