Severe COVID-19 patients develop encephalopathy over hours to days with some common symptoms like systemic inflammation, sepsis, hypoxia, cytokine storm and renal failure which is diagnosed by increase in the level of IL-2, IL-7, GCSF, IL-6, and TNF-alpha1[48] with no evidence of inflammation on CSF analysis.[45] IT was reported in 50% of hospitalized COVID-19 patients. This evidence concerns the gene IL6 and COVID-19.