After adjusting for potential confounders and other variables, the independent risk factors for TB/HIV co-infection mortality were as follows: having both EP and PTB coinfection (HR = 2.073, 95% CI = 1.020–4.216, P = .044), not initiated ART (HR = 2.534, 95% CI = 1.213–5.294, P = .013), and with the baseline CD4+T-lymphocyte count < 200 cells/μL (HR = 3.505, 95% CI = 1.104–11.129, P = .033) (Table 3). This evidence concerns the gene CD4 and tuberculosis.