Previous studies had identified that the expression of CHRDL1 was abnormal in many cancers including colorectal adenoma, GC and lung adenocarcinoma.[11,25,26] Additionally, CHRDL1 was considered as a prognosis predictor of lung adenocarcinoma and GC.[26,27] In our study, we found that the mRNA expression and protein expression levels of CHRDL1 were downgraded in THCA cells compared with normal cells. The gene discussed is CHRDL1; the disease is lung adenocarcinoma.