CHRDL1 and breast carcinoma: Wang et al found that CHRDL1 expression was regulated by hsa-microRNA-204 expression, which affected the invasion and proliferation of GC cells.[15] Meanwhile, Wang et al found that hsa-miR-204/CHRDL1 axis also affected the prognosis of breast cancer (BC).[16] Cyr-Depauw et al[17] claimed that CHRDL1 could inhibit the migration and invasion of BC cells to alleviate the prognosis of BC through inhibiting the bone morphogenetic protein 4 (BMP4) signal.