CHRDL1 and cancer: Chordin-like 1 (CHRDL1) is one of the secretory proteins.[10] Actually, CHRDL1 plays a vital role in the development of many cancers.[2] Previous studies showed that CHRDL1 usually had a downregulated expression and could reduce the ability of cell proliferation and migration in many tumors.[11,12] Moreover, CHRDL1 has been identified as a potential biomarker for cancer prognosis, including gastric cancer (GC) and THCA.[13,14] Besides, the mechanisms of CHRDL1 in some cancers have been reported.