In a mouse model of mild HF induced by transverse aortic constriction (TAC), PDE2 was found to be redistributed from β1AR (predominant association in healthy hearts) to β2AR, despite global PDE2 expression and activity being unchanged, leading to the hypothesis that such changes may promote the cardiac remodeling found in HF [67]. The gene discussed is ADRB2; the disease is hydrops fetalis.