However given the fact that the pathogenesis of acute COVID-19 is related to the interaction of the viral spike protein with the angiotensin-converting enzyme 2 (ACE 2), one could postulate that this pathway does not play an important role in long COVID compared to the residual inflammatory processes that seem to continue to occur in PASC (Nalbandian et al., 2021; Kaseb et al., 2021). This evidence concerns the gene ACE2 and COVID-19.