In colorectal cancer, the LILRB4 gene was found to be highly expressed in cancer tissue, and the expression level of the LILRB4 gene was negatively correlated with the density of CD45RO + T cells in the cancer tissue, and high LILRB4 gene expression was a biomarker of poor clinical prognosis for colorectal cancer [48]. The gene discussed is LILRB4; the disease is colorectal cancer.