It has been reported that SCUBE‐1 produced in megakaryocytes/platelets contributed to artery thrombosis in the absence of EC‐derived SCUBE‐1 and the its adhesive EGF‐like repeats are essential for crosslinking and stabilizing platelet aggregates during thrombus formation in vivo.13, 14. The gene discussed is SCUBE1; the disease is deep vein thrombosis.