In terms of animal model, we chose DNA Meiotic Recombinase 1 (Dmc1) gene knockout (Dmc1−/−) mice as therapeutic model due to its similar phenotypes to azoospermia in humans.[11] More importantly, Dmc1 mutation can lead to meiotic arrest as the Dmc1 protein plays a central role in meiosis by forming homologous recombination (HR) and repairing DNA breaks. Here, DMC1 is linked to Azoospermia.