In Pima Indians, an upstream variant (NC_000010.10: g.69635204T > A, rs10509291) and an intron variant (NC_000010.10: g.69651125A > G, rs7896005) in SIRT1 gene are associated with reduced insulin secretion and increased risk for T2D [48]. The gene discussed is INS; the disease is type 2 diabetes mellitus.