For example, we found that ALS risk leads to an increased expression of the SCFD1 gene in brain tissues, which is consistent with a previous study (Iacoangeli et al., 2021), as well as inferring increased levels of the SCFD1 protein in brain tissues accompanied by a decreased expression of the SCFD1 gene in the blood. Here, SCFD1 is linked to amyotrophic lateral sclerosis.