TLR4 and alkaline phosphatase measurement: Variants in the CRP, CCL2, CCL8, NOS1, NOS2, NOS3, IFNG, MMPs-2,3, 7, 8, 9, TIMP2, TLR4, PTGER2, and NFKB1 loci were also suggestively associated with AP (p < 9.4 × 10−4) (Supplementary Table 2).