PDC and Sepsis: Keenly aware that redox regulation of PDC in the face of the changing redox landscape of sepsis needs to be better understood, we set out to evaluate the glutathionylation status of PDC as it changes during acute inflammation stimulated by lipopolysaccharide (LPS) treatment (a model of sepsis) in human THP-1 promonocytic cells in culture and in freshly isolated monocytes from human blood.