Dong et al. uncovered that FBXL19 was a tumor suppressor in esophageal cancer, by regulating the degradation and ubiquitination of Rac3 protein which plays an important role in the progress of esophageal cancer cells, and then inhibiting the downregulation of cadherin induced by TGF Bata1 pathway [14]. The gene discussed is RAC3; the disease is esophageal cancer.