This paper focused on the analysis of DEGs whose expression was different with significance between the breast normal tissue and tumor tissue, and determined 5 genes (FBXL19, HAGHL, PHKG2, PKMYT1, and TXNDC17) as prognostic biomarkers for BRCA by WGCNA and Lasso-cox methods. This evidence concerns the gene PKMYT1 and neoplasm.