In parallel, we observed a constitutive activation of both kinases, in particular pFAK (Y397) was observed also in the nuclei of some CLL cells while p‐PYK2 (Y402) was more punctuated in podosome‐like structures31 (Figure 2D) possibly suggesting a different role or regulation for the two proteins. Here, PTK2B is linked to B-cell chronic lymphocytic leukemia.