ALS is a neuromuscular disorder resulting from protein inclusions formed from TAR DNA-binding protein of 43 kDa (TDP-43), Cu/Zn superoxide dismutase (SOD-1) or fused in sarcoma (FUS) within motor neurons [21], which result in loss of motor functions, progressive degeneration and ultimately death from asphyxiation or inanition [22]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.