Thirteen targets, including AKT1, TNF, SRC, VEGFA, EGFR, CASP3, MAPK3, STAT3, PPARG, ESR1, MTOR, PTGS2, and MAPK1, were proposed as the possible key targets of Rosa roxburghii Tratt fruit for T2DM treatment. Here, AKT1 is linked to type 2 diabetes mellitus.