As shown in Fig. 9, the 20 most significantly enriched pathways (P-value < 0.05), which identified, the PI3K (phosphatidylinositol 3-kinase)/AKT (serine/threonine kinase) signaling pathway, cancers, viral infection, and AGE-RAGE signaling pathway in diabetic complications. This evidence concerns the gene AKT1 and viral infectious disease.