Polyphenols of Rosa roxburghii Tratt exhibit good hypoglycemic effects by activating the P13K/AKT signaling pathway and regulating the expression of the Forkhead box protein O1 (FOXO1), and glycogen synthase kinase-3 beta (GSK-3β) proteins, controlling liver gluconeogenesis and improving insulin resistance to hepatic glycogen storage, to alleviate symptoms of T2DM [42]. The gene discussed is FOXO1; the disease is type 2 diabetes mellitus.