The objection of this project was to explore the biological functions of SLFN5 in human ovarian cancer both in vivo and in vitro, to identify the molecular target of SLFN5 in HO-8910 and SKOV3 cell lines and to uncover the potential mechanism of SLFN5 which promotes ovarian cancer development, in an attempt to provide a novel perspective and the oretical basis for clinical early diagnosis and therapy of ovarian cancer. This evidence concerns the gene SLFN5 and ovarian carcinoma.