In the laboratory examination, the value of CEA (21.73 ± 69.50 vs. 2.32 ± 1.52, P = 0.001) and the proportion of CEA > 5 ng/ml (32 [36.4%] vs. 2 [5.9%], P = 0.001) in nonmetastatic GBC were higher than those in cholecystitis. Here, CEACAM5 is linked to Cholecystitis.