The primary endpoint rate in the overall (non-matched) population was 20% (n = 29,032), and it was 17%, 16%, and 29%, in non-DM patients, in DM patients treated with GLP-1 RA/SGLT-2i, and in DM patients not treated with GLP-1 RA/SGLT-2i, respectively (Table 1). This evidence concerns the gene GLP1R and diabetes mellitus.