Multiple Cox regression analysis also revealed that WEE2-AS1 expression level was an independent determinant of the prognosis of OS in patients with glioma (HR = 2.002, 95% CI, 1.279–3.133, p = 0.002) after adjusting for age, primary therapy outcome, WHO grade, histological type, and IDH status. This evidence concerns the gene IDH1 and central nervous system cancer.