THY1 and neoplasm: In colorectal cancer, chemokine ligand 5 (CCL5) positively regulates the expression of a solute carrier family member (SLC25A24) in CD90+ fibroblasts and activates phosphorylated pAkt-pmTOR signaling, thereby increasing the number of CD90+ fibroblasts, and promoting tumor angiogenesis by enhancing VEGFA expression and transdifferentiating fibroblasts into vascular endothelial cells (Tancharoen et al. 2017; Gao et al. 2022).