THY1 and diabetes mellitus: In wound healing, the differentiation of fibroblasts into myofibroblasts is an important component, and the fibroblast subpopulation that can differentiate into myofibroblasts is mainly CD90+ fibroblasts (CD90− fibroblasts differentiate mainly into adipose fibroblasts), and the ECM of patients with diabetes mellitus (DM) exhibits fibroblast senescence, and their failure to differentiate to produce myofibroblasts leads to impaired wound healing (Kunkemoeller et al. 2017).