TRAEs of occurrence ≥ 10% were thyroid function test abnormal (26.1%), skin depigmentation (21.0%), rash (16.8%), aspartate aminotransferase increased (15.1%), hyperlipidaemia (13.4%), blood bilirubin increased (12.6%), alanine aminotransferase increased (12.6%), and hypothyroidism (12.6%) as shown in Table 4. This evidence concerns the gene GPT and hypothyroidism.