TNF and heart failure: A study in patients with heart failure and desynchrony (HFDYS), showed that miR-30d appears to be regulated by heart wall stress, consistent with its increased expression in the lateral wall in a canine model of HFDYS, which appears to play a functional role in cardiomyocyte biology, mediating cardiac hypertrophy with a distinct molecular signature and protecting against TNF-α–induced apoptosis and deleterious signaling18.