Based on the clinical symptoms, MRI, EEG, CSF changes, antibody titers, copositivity with other antibodies, response to immunotherapy and other significant findings (such as past history and pathological examinations), we conducted a comprehensive analysis of the 26 patients (Table 2) to distinguish between true- and false-positive cases of CASPR2-related autoimmunity and to explore the correlation between the clinical phenotype and positive anti-CASPR2 antibody. Here, CNTNAP2 is linked to Autoimmunity.