LGI1 and Autoimmunity: In a review of LGI1 and CASPR2 autoimmunity in children, 37 pediatric patients with CASPR2 and/or LGI1 autoimmunity were identified in the literature: 37.8% of patients had LGI1 antibodies, 37.8%had CASPR2 antibodies, and 24.3% of patients were double positive for LGI1 and CASPR2 antibodies12.