To address whether SPP1 is dysregulated at a time point whensynapses are vulnerable to microglial engulfment in an AD-relevant context, weused the slow-progressing AppNL-F mouse model, where control bythe endogenous App promoter allows forphysiological cell-type specific and temporal regulation of Aβproduction15,29,30. The gene discussed is SPP1; the disease is Alzheimer disease.