TUBB4A and amyotrophic lateral sclerosis: In order to model the effects of 8 mutations reported to be associated with ALS (A383T, G43V, K430N, T145P, R215C, R320H, R320C, and W407X) (Fig. 1D) on TUBA4A protein structure and function, we used computational modelling and atomistic molecular-dynamic simulation tools to analyze TUBA4A::TUBB4A dimerization, GTP binding, and microtubule assembly and stability.