CD8A and metastatic malignant neoplasm in the lymph nodes: The number of CD8+ TILs was significantly higher in cases without lymph node metastasis (median: 180/10 HPF, range 10–1042) than in those with lymph node metastasis (median: 42/10 HPF, range 15–394; P = 0.042; Fig. 3b).