In addition, the incidence of adverse effects, such as increased mean arterial blood pressure, diarrhea, hair color change, increase in alanine aminotransferase (ALT) level, stomatitis, and hand-foot syndrome increased based on the pazopanib trough concentrations, such that the highest incidence of adverse effects was observed in the fourth quartile of pazopanib trough concentrations9. The gene discussed is GPT; the disease is Hand-foot syndrome.