We then analyzed the impact of ImP expression on OS, as well as bone, brain, liver, lungs, skin and lymph node metastasis, and found that a high frequency of PSMB8-expressing cells correlated with fewer patients with bone and liver metastases, and a trend to fewer patients with brain metastases (Fig. S5A, right panels), while PSMB9 expression had no significant correlations for all breast cancer patients together (Fig. S5B, left panel). This evidence concerns the gene PSMB8 and breast carcinoma.