For example, high PSMB8 and PSMB9 expression correlates with better outcomes and response to immune checkpoint inhibitors for melanoma patients27 and PSMB8 overexpression in non-small cell lung cancer is associated with fewer cases of relapse and metastasis28, as well as better 5 years survival rates29. This evidence concerns the gene PSMB8 and non-small cell lung carcinoma.