IPF patient lung immunoreactivity was significantly higher than healthy lung controls for both antibodies (SMAD7: P = 0.0002 and OGG1: P = 0.0024), indicating the potential role of OGG1 and SMAD7 in IPF disease (Fig. 8c, d; Supp. Here, OGG1 is linked to idiopathic pulmonary fibrosis.