Interestingly, the clear plasma ofCS-CD44 amount-dependent risk for each kind of malignant tumor was detected, especially for colorectal cancer, nasopharyngeal carcinoma, esophageal squamous cell carcinoma, and cervical cancer, with a risk for the top decile ranging 8.9 to 25.5. Here, CD44 is linked to esophageal squamous cell carcinoma.