Importantly, KC;iASPPΔ8/Δ8 mice had greater extents of intratumoral Treg cell infiltration than KC mice in early ADM lesions (Fig. 3D), demonstrating that increased presence of Treg cells is dependent on loss of iASPP and not simply on more advanced pancreatic cancer. The gene discussed is CALCA; the disease is pancreatic neoplasm.