Importantly, KC;iASPPΔ8/Δ8 mice had greater extents of intratumoral Treg cell infiltration than KC mice in early ADM lesions (Fig. 3D), demonstrating that increased presence of Treg cells is dependent on loss of iASPP and not simply on more advanced pancreatic cancer. This evidence concerns the gene PPP1R13L and pancreatic neoplasm.