Although KrasLSL−G12D/+;Trp53LSL−R172H/+;Pdx1-Cre (KPC) mice developed the most accelerated progression to PDAC, KrasLSL−G12D/+;iASPPfl/fl;Pdx1-Cre (KC;iASPPΔ8/Δ8) mice paradoxically had advanced pancreatic neoplasia development compared to KrasLSL−G12D/+;Pdx1-Cre (KC) mice (Fig. 3A). The gene discussed is PDX1; the disease is keratoconus.