In concordance with pancreatic neoplasia findings, 15 weeks after intranasal delivery of adenovirus expressing Cre recombinase, deletion of iASPP in KrasLSL−G12D/+;iASPPfl/fl (Ki) mice elicited >7-fold increased tumor burden (p = 0.0107, Fig. 5B–D) and more advanced histological grade (p = 4.0 × 10–10) of lung cancer compared to KrasLSL−G12D/+ (K) mice (Fig. 5B). The gene discussed is PPP1R13L; the disease is lung carcinoma.