CD4 and pancreatic neoplasm: RNA-sequencing (RNA-seq) of pancreatic tumor lysates and principal component analysis revealed that KC;iASPPΔ8/Δ8 pancreata bear closer resemblance to KC than KPC pancreata (Fig. S6A) and express greater Cd3, Cd4, Itgae, Pdcd1, Il10, Ccl5, Osm, and Cd274 (Fig. S6B), reflective of an immunosuppressive stromal reaction.