Given that the elevated serum autoantibodies are crucial clinical characteristics of SS, and there were positive correlations of MDSCs with the levels of serum IgG, anti-SSA antibodies, anti-SSB antibodies, and ANA, we wonder whether IgG-containing SS medium can result in SS-MDSCs dysfunction to disturb CD4+ T-cell balances. This evidence concerns the gene BTG3 and synovial sarcoma.