AR and hepatocellular carcinoma: Our study demonstrated that AR-V7 and AR-FL (at a lesser level and male-specific manner) exacerbate the c-MYC-mediated hepatocarcinogenesis by potentiating the oncogenic and minimizing the anti-proliferative functions of c-MYC in the liver (Fig. 5), thereby providing critical insights into the molecular mechanisms partially responsible for the heterogeneity in HCC.