CLDN7 and cancer: By exploring the transcriptome data of the 222 c-MYC downstream genes whose expression levels were partly (41 genes) or completely (181 genes) repressed by AR-V7 co-expression (green and blue areas in Fig. 2A and Supplementary Table 4), we found that the tumor suppressor gene Claudin 7 (Cldn7) was upregulated more than 40 folds in hep-c-MYC cancer compared to control liver, whereas such upregulation was reversed in the hep-c-MYC/AR-V7 cancer in both male and female mice (Fig. 4A).