The present study showed that AR-V7 could exacerbate in both sexes and AR-FL could exacerbate in a male-biased manner the c-MYC oncogenic actions in HCC development (Fig. 1), suggesting that AR-V7 and AR-FL promote the c-MYC-driven oncogenesis, thereby contributing to the heterogeneity and sexual dimorphisms in HCC initiation and progression respectively. The gene discussed is MYC; the disease is hepatocellular carcinoma.