The co-expression of Cldn7FLAG significantly diminished the hep-c-MYC/p53KO cancer development, and the overall tumor volume in the hep-c-MYC/p53KO/Cldn7FLAG mice was equivalent to that of hep-c-MYC mice at 11 dpi (Fig. 4E, F). The gene discussed is MYC; the disease is neoplasm.