BMP4 and ischemia: Intriguingly, HIF-1α is predicted by bioinformatics analysis to be a potential transcriptional factor binding to the Bmp4 promoter, suggesting that hypoxia or ischemia-induced HIF-1α may bind to the promoter region of Bmp4 and activate its transcription and expression to protect the myocardium from hypoxia/reoxygenation or ischemia/reperfusion injury.