NFATC3 and brain injury: In a rat model of traumatic brain injury (TBI) and in the 5xFAD mouse model of amyloid pathology, NFAT4 activity was 2.5–4-fold higher than in wild-type mice and sham-injured rats, respectively, and was associated with irreversible proteolytic modifications to CN resulting in constitutive Ca2+-independent phosphatase activity (Furman et al., 2016; Sompol et al., 2017).