Interestingly, somatic mutations in NLRP3 together with 10 other genes including KEAP1, KRAS, and STK11 were reported to define a molecular signature associated with a subtype of NSCLC, the lung adenocarcinoma (LUAD) (Hoadley et al, 2013). This evidence concerns the gene KEAP1 and non-small cell lung carcinoma.