NLRP3 and neoplasm: Finally, to address whether the introduction of NLRP3 into NLRP3-deficient NSCLC tumor cell lines would improve ATM activation, we re-expressed NLRP3 using a doxycycline-inducible system in A549 and H292 cells, and evaluated ATM activation after IR by assessing the number of P-ATM and γH2AX foci.