BCL6 and Cowden disease: BCL6 builds a compelling case as a potential novel target for ileal CD, since it modulates follicular helper T-cells, follicular regulatory T-cells61 in IBD, controls the inflammatory activity of regulatory T-cells,62 and drives the formation of the Th17 lineage of T-cells63 which characterise ileal CD.6 64 However, despite its potential disease relevance, further investigations need to be carried out to ascertain the (side)effects on other T-cell lineages when BCL6 would be targeted.