CD4 and inflammatory bowel disease: To substantiate the functional importance of the two phenotypically relevant CD4 T cell signature associated with disease location, the signature genes were matched against pre-existing gene sets corresponding to IBD drug targets,34 IBD relevant genes (barrier function,35 antimicrobial peptides,36 cell-adhesion molecules,37 IBD susceptibility loci,38 literature search) and IBD eQTLs39 (figure 4A).