In total, only 4 (CXCR4, PRKCQ, PTGER4 and SMAD7) of the 57 disease location-associated genes relevant to IBD pathogenesis were known to be therapeutic targets in IBD, signifying the discovery of novel and additional targets with therapeutic potential (figure 4A–B, online supplemental table 6). The gene discussed is PTGER4; the disease is inflammatory bowel disease.