KLF4 and inflammatory bowel disease: However, genes (BCL6, CDKN1A, BTG1, GADD45A, KLF4) (figure 3A–C) within the downregulated FOXO-pathway (which was one among the pathways consistently found to be over-represented among feature sets inferred by multiple methods) have not yet been targeted in IBD as well as other IMIDs (PS, RA, SC and SA).