However, genes (BCL6, CDKN1A, BTG1, GADD45A, KLF4) (figure 3A–C) within the downregulated FOXO-pathway (which was one among the pathways consistently found to be over-represented among feature sets inferred by multiple methods) have not yet been targeted in IBD as well as other IMIDs (PS, RA, SC and SA). Here, CDKN1A is linked to inflammatory bowel disease.