CRP and Stroke: While circulating levels of several proteins are assessed in the acute phase of stroke to detect systemic complications of stroke (e.g. CRP, GOT, GPT66), there is no circulating protein that supports clinical decisions by reliably detecting local pathophysiological processes in stroke, e.g. vessel occlusion, (ischemic) neuro(axo)nal injury, blood–brain barrier dysfunction, and the local immune response.