VDR and cancer: Cholecalciferol or vitamin D3 (VD3) plays a key role in bone metabolism and calcium homeostasis, however, this hormone is capable of exerting extra-skeletal activities such as in cellular physiology, antiproliferative effects on cancer cells (Trochoutsou et al., 2015), modulation of the immune response and control of inflammation, roles performed through the binding to the Vitamin D Receptor (VDR) (Sassi et al., 2018).