TARDBP and amyotrophic lateral sclerosis: Western blot analysis showed that all sarkosyl-insoluble protein extracts from five sporadic ALS patients contained both full-length and C-terminal fragments (CTFs) of pTDP-43 (pS409/410), consistent with the biochemical profile of pathological TDP-43 in sporadic ALS (Fig 1) [2,3,22].