KRT14 and COVID-19: To further test the requirement for SARS-CoV-2 infection of the OE and brain for lethal COVID-19 in hACE2fl/y mice, we generated Foxg1Cre/+; hACE2fl/y mice in which Cre recombinase is expressed in the RE, OE, and neurons of the forebrain, but not in cells of the lung [55] (Figs 6H and S10), and K14-Cre; hACE2fl/y mice in which Cre recombinase is expressed in RE and transition zone epithelial cells of the nasal cavity (Keratin-14; S11A Fig).