KRT14 and infection: Following exposure to SARS-CoV-2, both hACE2fl/y and K14-Cre; hACE2fl/y mice exhibited weight loss and lethality associated with severe hypoxemia (S11B–S11D Fig), although K14-Cre; hACE2fl/y mice demonstrated absence of SARS-CoV-2 nucleocapsid staining in the nasal RE, consistent with a lack of infection at that site (S11E Fig).