In line with the enrichment for multiple immune-related functions, these genes also exhibited significant overlap with gene sets that have been associated with Coronavirus Disease 2019 (COVID-19), including genes whose expression changes upon Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and genes predicted to be functionally related to ACE2 (S16 Fig), although ACE2 itself did not show a strong seasonal pattern. This evidence concerns the gene ACE2 and COVID-19.